Dnaaf2 Gene Summary [Rat]
Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and epithelial cilium movement involved in extracellular fluid movement. Predicted to act upstream of or within several processes, including axonemal dynein complex assembly; establishment of left/right asymmetry; and response to retinoic acid. Predicted to be located in several cellular components, including ciliary basal body; dynein axonemal particle; and nuclear lumen. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 10. Orthologous to human DNAAF2 (dynein axonemal assembly factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaaf2 |
| Official Name | dynein, axonemal, assembly factor 2 [Source:RGD Symbol;Acc:1310311] |
| Ensembl ID | ENSRNOG00000028155 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, assembly factor 2 |
| Synonyms | C14orf104, CILD10, dynein axonemal assembly factor 2, dynein, axonemal assembly factor 2, dynein, axonemal, assembly factor 2, kintoun, KTU, mknt, PF13, RGD1310311, TU54 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnaaf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PIH1 CS-like domain
- alpha-crystallin Hsps/p23-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary ciliary dyskinesia
- primary ciliary dyskinesia type 10
- situs ambiguus
- situs inversus totalis
- growth failure
- androgenic alopecia
- hydrocephalus
- dextrocardia
- situs inversus
regulates
- Axonemal Dynein
- Axonemal Dynein Outer Arm
- Axonemal Dynein Inner Arm
role in cell
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- cilia
- basal bodies
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- perinuclear focus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnaaf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- outer dynein arm assembly
- in utero embryonic development
- axonemal dynein complex assembly
- ciliary cell motility
- epithelial cilium movement
- establishment of localization in cell
- inner dynein arm assembly
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding