Serpinb13 Gene Summary [Rat]
Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity and negative regulation of keratinocyte apoptotic process. Predicted to be located in cytosol and nuclear speck. Predicted to be active in extracellular space. Orthologous to human SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb13 |
| Official Name | serpin family B member 13 [Source:RGD Symbol;Acc:1304661] |
| Ensembl ID | ENSRNOG00000028194 |
| Bio databases IDs | |
| Aliases | serpin family B member 13 |
| Synonyms | 5430417G24, headpin, HSHUR7SEQ, HUR7, HURPIN, PI13, serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13, serpin family B member 13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinb13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine protease inhibitor activity
- protease binding
- SERine Proteinase INhibitors (serpin) family
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- diabetes mellitus
- ulcer
- melanoma cancer
- melanoma
- atopic dermatitis
- actinic keratosis
- skin squamous cell carcinoma
- squamous cell skin cancer
- skin basal cell carcinoma
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- lysosomal compartment
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinb13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteolysis
- negative regulation of endopeptidase activity
- response to UV
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- cytosol
- lysosomal lumen
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- cysteine-type endopeptidase inhibitor activity
- protease binding