Sco1 Gene Summary [Rat]
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Sco1 |
| Official Name | SCO cytochrome c oxidase assembly protein 1 [Source:RGD Symbol;Acc:1559538] |
| Ensembl ID | ENSRNOG00000028699 |
| Bio databases IDs | |
| Aliases | SCO cytochrome c oxidase assembly protein 1 |
| Synonyms | 2610001C07Rik, D11Bwg1310e, MC4DN4, RGD1559538, SCO1 cytochrome c oxidase assembly protein, SCOD1, synthesis of cytochrome C oxidase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sco1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- SCO1/SenC
- AhpC/TSA family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 4 mitochondrial complex IV deficiency
- mitochondrial disorder
- nuclear type 1 mitochondrial complex iv deficiency
regulates
- lipid
- iron ion
- Cu2+
- PGAM5
- Zn2+
role in cell
- organization
- differentiation
- homeostasis in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sco1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
- cellular copper ion homeostasis
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- copper chaperone activity