Akap1 Gene Summary [Rat]
Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to cAMP; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein import into nucleus. Located in lipid droplet; mitochondrial crista; and postsynaptic membrane. Is active in neuromuscular junction and postsynaptic specialization, intracellular component. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap1 |
| Official Name | A-kinase anchoring protein 1 [Source:RGD Symbol;Acc:620826] |
| Ensembl ID | ENSRNOG00000002373 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 1 |
| Synonyms | AKAP, AKAP121, AKAP149, AKAP84, A-kinase anchoring protein 1, A kinase anchor protein 1, D-AKAP1, LOC100911629, PPP1R43, PRKA1, S-AKAP84, TDRD17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- protein kinase A binding
- Tudor domain
- protein kinase binding
- protein phosphatase binding
- leucine zipper domain
- PP1 binding domain
- R2 binding domain
- K homology RNA-binding domain
- protein binding
- RNA binding
- microtubule binding
- PKA anchoring domain
- KH domain
- K homology (KH) RNA-binding domain, type I
- protein phosphatase 2B binding
- RII binding domain
- Tudor domain superfamily
- Dbl homology domain
- RI/RII binding domain
Pathways
Biological processes and signaling networks where the Akap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- osteoarthritis
- neurological signs
- Alzheimer disease
- mucoepidermoid carcinoma
- acinar-cell carcinoma
- salivary duct carcinoma
- salivary duct cancer
role in cell
- expression in
- binding in
- production in
- phosphorylation in
- apoptosis
- migration
- formation
- proliferation
- tubulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pH resistant lipid raft fraction
- organelle
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- postsynaptic membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- protein kinase A regulatory subunit binding