Abcc5 Gene Summary [Rat]
Predicted to enable several functions, including ABC-type xenobiotic transporter activity; glutathione transmembrane transporter activity; and heme transmembrane transporter activity. Involved in response to insulin and response to lipopolysaccharide. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcc5 |
| Official Name | ATP binding cassette subfamily C member 5 [Source:RGD Symbol;Acc:70913] |
| Ensembl ID | ENSRNOG00000029178 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 5 |
| Synonyms | 2900011L11Rik, ABC33, ABCC5A, Abcc5b, ATP binding cassette subfamily C member 5, ATP-binding cassette, sub-family C member 5, EST277145, MOAT-C, MRP5, pABC11, SMRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- efflux permease
- ATP binding
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- purine nucleotide transporter
- thiol reductant ABC exporter, CydC subunit
- xenobiotic-transporting ATPase
- multi drug resistance-associated protein (MRP)
- nickel import ATP-binding protein NikE
- thiamine ABC transporter, ATP-binding protein
- heme transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- organic anion transporter
- inorganic anion transporter
- tripeptide transporter
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- cystic fibrosis transmembrane conductor regulator (CFTR)
- xenobiotic transporter
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- primary biliary cirrhosis
- breast cancer
- mammary neoplasm
- epilepsy
- metabolic syndrome X
- clonal hematopoiesis
regulates
- xenobiotic
- cyclic GMP
- alaninyl-d4TMP
- adefovir
- beta-citrylglutamic acid
- hyaluronic acid
- N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
- methotrexate glutamate3
- cyclic AMP
- beta-citryldiglutamate
role in cell
- growth
- cell death
- drug resistance
- cytotoxicity
- cytostasis
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drug transmembrane transport
- transmembrane transport
- heme transmembrane transport
- xenobiotic metabolic process
- cGMP transport
- glutathione transmembrane transport
- xenobiotic transport
- cAMP transport
- hyaluronan biosynthetic process
- purine nucleotide transport
Cellular Component
Where in the cell the gene product is active
- membrane
- endosome membrane
- Golgi lumen
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- xenobiotic transporter activity
- ATPase activity, coupled to transmembrane movement of substances
- efflux transmembrane transporter activity
- heme transporter activity
- xenobiotic-transporting ATPase activity
- organic anion transmembrane transporter activity
- anion transmembrane-transporting ATPase activity
- macromolecule transmembrane transporter activity
- ATP binding
- purine nucleotide transmembrane transporter activity
- glutathione transmembrane transporter activity