Rnf213 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; lipid droplet formation; and protein ubiquitination. Predicted to be located in cytoplasm and lipid droplet. Predicted to be active in cytosol and nucleolus. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf213 |
| Official Name | ring finger protein 213 [Source:RGD Symbol;Acc:1308168] |
| Ensembl ID | ENSRNOG00000029658 |
| Bio databases IDs | |
| Aliases | ring finger protein 213 |
| Synonyms | 6030403J01, ALO17, C17ORF27, D11Ertd759e, FRAG-6, KIAA1554, KIAA1618, LOC100287062, MYMY2, mysterin, MYSTR, NET57, RGD1308168, ring finger protein 213 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnf213 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- Family of unknown function (DUF6539)
- enzyme
- protein binding
- ATPase
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to moyamoya disease type 2
- Moyamoya disease
- familial multiple sclerosis
- hereditary disorder
- epithelial cancer
- major depression
- headache
- prostate cancer
- Huntington disease
- migraines
regulates
- Ins1
- lipid
- D-glucose
role in cell
- formation
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- lipid droplets
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnf213 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- negative regulation of non-canonical Wnt receptor signaling pathway
- sprouting angiogenesis
- protein K63-linked ubiquitination
- regulation of lipid metabolic process
- defense response to bacterium
- immune system process
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ubiquitin-protein ligase activity
- metal ion binding