Tcl1a Gene Summary [Rat]
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | Tcl1a |
| Official Name | T-cell leukemia/lymphoma 1A [Source:RGD Symbol;Acc:1594686] |
| Ensembl ID | ENSRNOG00000025233 |
| Bio databases IDs | |
| Aliases | T-cell leukemia/lymphoma 1A |
| Synonyms | LOC683950, T cell leukaemia/lymphoma 1A, T cell leukemia/lymphoma 1A, T cell lymphoma breakpoint 1, TCL1, TCL1 family AKT coactivator A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tcl1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- transcription regulator
- protein kinase binding
- TCL1/MTCP1 family
- Akt-binding domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Tcl1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- hepatomegaly
- cancer
- splenomegaly
- B-cell non-Hodgkin disease
- non-Hodgkin disease
- B cell cancer
- mature B-cell neoplasia
- lymphomagenesis
role in cell
- expression in
- proliferation
- activation
- apoptosis
- transmembrane potential
- activation in
- number
- growth
- cellular infiltration by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell cortex
- Endoplasmic Reticulum
- cytosol
- microsome
- nucleoplasm
- pronucleus
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tcl1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding