Cd209b Gene Summary [Mouse]
Enables (1->3)-beta-D-glucan binding activity and D-mannose binding activity. Acts upstream of or within several processes, including detection of other organism; phagocytosis, recognition; and positive regulation of tumor necrosis factor production. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease (multiple); aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cd209b |
| Official Name | CD209b antigen [Source:MGI Symbol;Acc:MGI:1916415] |
| Ensembl ID | ENSMUSG00000065987 |
| Bio databases IDs | |
| Aliases | CD209b antigen |
| Synonyms | 1810030I22Rik, CD209b antigen, Clec4m, C-type lectin domain family 4 member M, DC-SIGNR1, mSIGNR1, OtB7, SIGNR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd209b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- viral receptor
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- Lectin C-type domain
- carbohydrate binding
- polysaccharide binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- zymosan
- ICAM2
- ICAM3
disease
- dextran sodium sulfate-induced colitis
- endotoxin shock response
- colitis
- septic shock
- infection by bacteria
- infection by lentivirus
role in cell
- number
- production in
- phagocytosis by
- function
- detection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face