Bsn Gene Summary [Rat]
Enables dynein light chain binding activity; enzyme inhibitor activity; and transcription corepressor binding activity. Involved in several processes, including presynaptic active zone assembly; regulation of ubiquitin protein ligase activity; and retrograde axonal transport. Located in several cellular components, including axon cytoplasm; cytoplasmic vesicle; and cytoskeleton of presynaptic active zone. Is active in several cellular components, including GABA-ergic synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic active zone cytoplasmic component. Orthologous to human BSN (bassoon presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bsn |
| Official Name | bassoon (presynaptic cytomatrix protein) [Source:RGD Symbol;Acc:2223] |
| Ensembl ID | ENSRNOG00000030714 |
| Bio databases IDs | |
| Aliases | bassoon (presynaptic cytomatrix protein) |
| Synonyms | Bassoon, bassoon (presynaptic cytomatrix protein), bassoon presynaptic cytomatrix protein, ZNF231 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bsn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- enzyme inhibitor activity
- Golgi binding region
- transcription factor binding
- coiled-coil domain
- protein binding
- core domain, functional
- FYVE domain like superfamily
- CAST binding domain
- Piccolo Zn-finger
- dynein light chain binding
- zinc finger domain
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- coronary artery disease
- chronic obstructive pulmonary disease
- epilepsy
- insomnia
- prostatic carcinoma
- prostate cancer
- pervasive developmental disorder
- epileptic seizure
- Crohn disease
role in cell
- quantity
- formation
- branching
- assembly
- number
- clustering
- synaptic transmission
- clustering in
- organization in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- membrane fraction
- presynaptic active zone
- glutaminergic synapse
- proximal axon
- cortical cytoskeleton
- cytoskeleton
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
- cell cortex
- Nucleus
- Golgi Apparatus
- cytosol
- presynaptic membrane
- synaptic membrane
- trans Golgi network
- dendritic spines
- synaptic vesicles
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- transport vesicles
- cellular protrusions
- perikaryon
- axons
- dendrites
- postsynaptic density
- presynaptic terminals
- ribbon synapse
- excitatory synapses
- dendritic shafts
- axonal shafts
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bsn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of presynaptic active zone structure
- regulation of synaptic transmission
- synaptic vesicle clustering
- synaptic transmission
- protein localization to synapse
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- nucleus
- presynaptic active zone
- synaptic vesicle
- excitatory synapse
- presynaptic cytoskeletal matrix assembled at active zones
- synaptic vesicle membrane
- axon
- neuron projection terminus
- cell surface
Molecular Function
What the gene product does at the molecular level
- enzyme inhibitor activity
- metal ion binding