Il1rap Gene Summary [Rat]
Enables interleukin-1 receptor binding activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Part of protein-containing complex. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1rap |
| Official Name | interleukin 1 receptor accessory protein [Source:RGD Symbol;Acc:2893] |
| Ensembl ID | ENSRNOG00000001928 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor accessory protein |
| Synonyms | 6430709H04RIK, C3orf13, IL1R3, IL-1RAcP, Il1racpb, Il-1 receptor accessory, ILRAP, interleukin 1 receptor accessory protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il1rap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Box III domain
- immunoglobulin domain
- protein binding activity, bridging
- SEFIR domain
- protein binding
- TIR domain
- interleukin-1 receptor
- interleukin-1 binding
- interleukin-1 receptor binding
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- cytokine receptor
- transmembrane receptor
- tyrosine phosphorylation site
- coreceptor
Pathways
Biological processes and signaling networks where the Il1rap gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- obesity
- epithelial cancer
- eosinophilia
- hyperplasia
- systemic lupus erythematosus
- hepatocellular carcinoma
- liver cancer
- renal cell cancer
- severe asthma
role in cell
- expression in
- activation in
- density
- quantity
- response
- colony formation by
- infiltration by
- assembly
- adhesion
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- cellular membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il1rap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- positive regulation of interleukin-13 production
- macromolecular complex assembly
- innate immune response
- interleukin-1-mediated signaling pathway
- positive regulation of interleukin-6 production
- positive regulation of synapse assembly
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of interleukin-4 production
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-33 receptor activity
- coreceptor activity
- NAD+ nucleosidase activity
- interleukin-1 receptor activity
- interleukin-1 receptor binding