Acsm5 Gene Summary [Rat]
Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ACSM5 (acyl-CoA synthetase medium chain family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsm5 |
| Official Name | acyl-CoA synthetase medium-chain family member 5 [Source:RGD Symbol;Acc:1309578] |
| Ensembl ID | ENSRNOG00000031211 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase medium-chain family member 5 |
| Synonyms | Aa2-174, acyl-CoA synthetase medium-chain family member 5, C730019D22, C730027J19Rik, Cc1-38, FLJ20581, RGD1309578 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP-binding enzyme
- acetate--CoA ligase
- benzoate-CoA ligase family
- Adenylate forming domain, Class I superfamily
- enzyme
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
role in cell
- apoptosis
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- medium-chain fatty acid-CoA ligase activity
- GTP binding
- ATP binding
- metal ion binding
- fatty-acyl-CoA synthase activity
- fatty acid ligase activity