Adipoq Gene Summary [Rat]
Enables identical protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to epinephrine stimulus; and positive regulation of protein phosphorylation. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; glucose metabolism disease (multiple); hyperthyroidism; obesity; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); liver disease (multiple); primary open angle glaucoma; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adipoq |
| Official Name | adiponectin, C1Q and collagen domain containing [Source:RGD Symbol;Acc:628748] |
| Ensembl ID | ENSRNOG00000001821 |
| Bio databases IDs | |
| Aliases | adiponectin, C1Q and collagen domain containing |
| Synonyms | ACDC, ACRP30, Ad, Adid, adipo, Adipocyte complement related protein of 30 kda, ADIPOD, ADIPONECTIN, adiponectin, C1Q and collagen domain containing, ADIPQTL1, Adn, ADPN, APM-1, APN, GBP28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adipoq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- collagen binding domain
- variable domain
- globular domain
- hormone
- protein binding
- receptor binding
- identical protein binding
- globular head domain
- protein kinase activator
- binding protein
- protein homodimerization
- Collagen triple helix repeat (20 copies)
- C1q domain
Pathways
Biological processes and signaling networks where the Adipoq gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- obesity
- rheumatoid arthritis
- demyelination
- insulin resistance
- kidney disease
- neoplasia
- nonalcoholic steatohepatitis
- impaired glucose tolerance
- lipopolysaccharide induced acute lung injury
role in cell
- activation in
- phosphorylation in
- expression in
- depolarization
- growth
- number
- recruitment in
- proliferation
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adipoq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cAMP-dependent protein kinase activity
- negative regulation of gluconeogenesis
- glucose metabolic process
- positive regulation of fatty acid metabolic process
- brown fat cell differentiation
- positive regulation of protein kinase A signaling cascade
- fatty acid beta-oxidation
- response to glucose stimulus
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- negative regulation of macrophage differentiation
- positive regulation of metanephric glomerular visceral epithelial cell development
- negative regulation of protein autophosphorylation
- negative regulation of tumor necrosis factor production
- negative regulation of DNA biosynthetic process
- low-density lipoprotein particle clearance
- generation of precursor metabolites and energy
- negative regulation of inflammatory response
- negative regulation of synaptic transmission
- negative regulation of blood pressure
- response to nutrient
- positive regulation of signal transduction
- circadian rhythm
- positive regulation of interleukin-8 production
- regulation of glucose metabolic process
- fatty acid oxidation
- glucose homeostasis
- cellular response to cAMP
- gene expression
- negative regulation of macrophage derived foam cell differentiation
- detection of oxidative stress
- response to activity
- protein localization in plasma membrane
- negative regulation of granulocyte differentiation
- negative regulation of cell migration
- response to tumor necrosis factor
- negative regulation of phagocytosis
- positive regulation of monocyte chemotactic protein-1 production
- negative regulation of MAP kinase activity
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- cellular response to insulin stimulus
- response to ethanol
- cellular response to epinephrine stimulus
- response to glucocorticoid stimulus
- positive regulation of cholesterol efflux
- positive regulation of renal albumin absorption
- response to linoleic acid
- negative regulation of intracellular protein transport
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of metanephric mesenchymal cell migration
- positive regulation of myeloid cell apoptotic process
- signal transduction
- negative regulation of receptor binding
- negative regulation of fat cell differentiation
- positive regulation of glucose import
- negative regulation of hormone secretion
- response to sucrose stimulus
- response to bacterium
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of protein phosphorylation
- negative regulation of heterotypic cell-cell adhesion
- cellular response to xenobiotic stimulus
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
- negative regulation of platelet-derived growth factor receptor signaling pathway
- positive regulation of glycogen (starch) synthase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- endoplasmic reticulum
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein serine/threonine kinase activator activity
- sialic acid binding
- cytokine activity
- extracellular matrix structural constituent
- receptor binding
- hormone activity