Ppox Gene Summary [Rat]
Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppox |
| Official Name | protoporphyrinogen oxidase [Source:RGD Symbol;Acc:1310543] |
| Ensembl ID | ENSRNOG00000003567 |
| Bio databases IDs | |
| Aliases | protoporphyrinogen oxidase |
| Synonyms | PPO, protoporphyrinogen oxidase, V290M, VP, VPCO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- protoporphyrinogen oxidase
- flavin adenine dinucleotide binding
- NAD(P)-binding Rossmann-like domain
- FAD dependent oxidoreductase
- enzyme
- protein binding
- Flavin containing amine oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- porphyria variegata
- childhood-onset variegate porphyria
- sickle cell anemia
role in cell
- expression in
- proliferation
- accumulation in
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme O biosynthetic process
- porphyrin-containing compound biosynthetic process
- heme biosynthetic process
- heme a biosynthetic process
- protoporphyrinogen IX biosynthetic process
- heme b biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- flavin adenine dinucleotide binding
- oxygen-dependent protoporphyrinogen oxidase activity