Cdc42ep3 Gene Summary [Rat]
Predicted to be located in actin cytoskeleton and plasma membrane. Orthologous to human CDC42EP3 (CDC42 effector protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc42ep3 |
| Official Name | CDC42 effector protein 3 [Source:RGD Symbol;Acc:1305858] |
| Ensembl ID | ENSRNOG00000032136 |
| Bio databases IDs | |
| Aliases | CDC42 effector protein 3 |
| Synonyms | 3200001F04Rik, BORG2, CDC42 effector protein 3, CEP3, UB1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdc42ep3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdc42 effector
- CRIB
- protein binding
- cytoskeletal regulatory protein binding
Pathways
Biological processes and signaling networks where the Cdc42ep3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary thyroid carcinoma
- squamous cell lung cancer
- neoplasia
- lung squamous cell carcinoma
- chronic lymphocytic leukemia
- atrial fibrillation
- astrocytoma
- glioma formation
- oligodendroglioma
- chronic fatigue syndrome
role in cell
- proliferation
- migration
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- cytosol
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdc42ep3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of pseudopodium assembly
- signal transduction
- positive regulation of actin filament polymerization
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- actin cytoskeleton
- cytosol
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytoskeletal regulatory protein binding
- small GTPase binding