Scn10a Gene Summary [Rat]
Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential and voltage-gated sodium channel activity. Involved in odontogenesis of dentin-containing tooth and sodium ion transport. Located in axon. Part of clathrin complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn10a |
| Official Name | sodium voltage-gated channel alpha subunit 10 [Source:RGD Symbol;Acc:3629] |
| Ensembl ID | ENSRNOG00000032473 |
| Bio databases IDs | |
| Aliases | sodium voltage-gated channel alpha subunit 10 |
| Synonyms | FEPS2, Na(V)1.8, Nav1.8, PN3, SNS, sodium channel, voltage-gated, type X, alpha, sodium channel, voltage-gated, type X, α, sodium voltage-gated channel alpha subunit 10, sodium voltage-gated channel α subunit 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scn10a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- voltage-gated sodium channel
- Cytoplasmic domain of voltage-gated Na+ ion channel
- Ion transport protein
- ion channel binding
- protein binding
- basic domain
- voltage-gated ion channel
- acidic domain
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Scn10a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertensive arterial disease
- systemic lupus erythematosus
- knee osteoarthritis
- osteoarthritis
- cancer
- acute postoperative pain
- pain
- idiopathic scoliosis
- hypertension
- atrial fibrillation
role in cell
- accumulation in
- excitability
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scn10a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- regulation of heart rate
- regulation of atrial cardiomyocyte membrane depolarization
- regulation of AV node cardiac muscle cell action potential
- regulation of ion transmembrane transport
- sodium ion transmembrane transport
- odontogenesis of dentin-containing tooth
- regulation of bundle of His cardiac muscle cell action potential
- membrane depolarization involved in regulation of action potential
- regulation of cardiac muscle contraction
- sensory perception
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- extracellular vesicular exosome
- voltage-gated sodium channel complex
- clathrin complex
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ion channel binding
- voltage-gated sodium channel activity