Psen2 Gene Summary [Rat]
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Involved in response to hypoxia. Located in early endosome; synaptic membrane; and synaptic vesicle. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psen2 |
| Official Name | presenilin 2 [Source:RGD Symbol;Acc:621060] |
| Ensembl ID | ENSRNOG00000002879 |
| Bio databases IDs | |
| Aliases | presenilin 2 |
| Synonyms | AD3L, AD3LP, AD4, Ad4h, AI266870, ALG-3, CMD1V, E5-1, presenilin 2, PS-2, PSNL2, STM2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psen2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartic endopeptidase, intramembrane cleaving
- endopeptidase
- Presenilin
- catalytic domain
- hydrophilic domain
- peptidase
- transmembrane domain
- protein binding
- loop domain
- Signal peptide peptidase
- hydrophilic loop domain
Pathways
Biological processes and signaling networks where the Psen2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Notch Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- neoplasia
- bleeding
- hyperkeratosis
- acute myeloid leukemia
- leiomyomatosis
- dermatological disorder
- leukocytosis
- Alzheimer disease type 4
- Alzheimer disease
role in cell
- proliferation
- expression in
- activation in
- phosphorylation in
- formation
- apoptosis
- quantity
- cell death
- activation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoplasmic fraction
- raft fractions
- endoplasmic reticulum fraction
- membrane fraction
- glutaminergic synapse
- cell surface
- perinuclear region
- intracellular membranes
- cellular membrane
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cytosol
- endoplasmic reticulum membrane
- caveolar membranes
- presynaptic membrane
- synaptic membrane
- Golgi membrane
- inner nuclear membrane
- nuclear envelope
- synaptic vesicles
- dendrite initial segments
- Z line
- early endosomes
- rough endoplasmatic reticulum
- kinetochores
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psen2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- response to hypoxia
- calcium ion homeostasis
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- Notch receptor processing
- protein processing
- intracellular signal transduction
- beta-amyloid formation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synaptic vesicle
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- kinetochore
- plasma membrane
- endoplasmic reticulum membrane
- centrosome
- nuclear inner membrane
- early endosome
- membrane
- gamma-secretase complex
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- aspartic endopeptidase activity, intramembrane cleaving