Prx Gene Summary [Rat]
Involved in axon ensheathment and nerve development. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prx |
| Official Name | periaxin [Source:RGD Symbol;Acc:619960] |
| Ensembl ID | ENSRNOG00000018369 |
| Bio databases IDs | |
| Aliases | periaxin |
| Synonyms | CMT4F, L-Periaxin, periaxin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Cornifin (SPRR) family
- canonical PDZ domain
- protein binding
- PDZ domain
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- glioblastoma
- weight loss
- allodynia
- acute myeloid leukemia
- colorectal carcinoma
- colorectal carcinomagenesis
- Charcot-Marie-Tooth disease type 4
- renal clear cell adenocarcinoma
role in cell
- pyroptosis
- action potential
- abnormal morphology
- stabilization
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- axon ensheathment
- peripheral nervous system myelin maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- anchoring junction
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding