Srp54a Gene Summary [Rat]
Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; exocrine pancreas development; and neutrophil chemotaxis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srp54a |
| Official Name | signal recognition particle 54A [Source:RGD Symbol;Acc:621390] |
| Ensembl ID | ENSRNOG00000032776 |
| Bio databases IDs | |
| Aliases | signal recognition particle 54A |
| Synonyms | SCN8, signal recognition particle 54, signal recognition particle 54A, Srp54a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srp54a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CobQ/CobB/MinD/ParA nucleotide binding domain
- GTPase
- enzyme
- protein binding
- Signal peptide binding domain
- GTP binding
- signal recognition particle protein SRP54
- signal recognition particle protein
- 7S RNA binding
- SRP54-type protein, GTPase domain
- SRP54-type protein, helical bundle domain
- GDP binding
- ribonucleoprotein binding
- signal sequence binding
- signal recognition particle-docking protein FtsY
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Waldenström macroglobulinemia
- autosomal dominant severe congenital neutropenia type 8
- hereditary disorder
- Shwachman-Diamond syndrome type 1
- primary ciliary dyskinesia type 40 with situs inversus
- metabolic syndrome X
regulated by
- Brucella abortus
- RAB1B
- SEC61
- imipramine
role in cell
- expression in
- phosphorylation in
- differentiation
- proliferation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srp54a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
- neutrophil chemotaxis
- protein targeting to ER
- exocrine pancreas development
- granulocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- endoplasmic reticulum
- nucleolus
- signal recognition particle, endoplasmic reticulum targeting
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATPase activity
- endoplasmic reticulum signal peptide binding
- RNA binding
- protein binding
- GTPase activity
- ribonucleoprotein complex binding
- GDP binding
- 7S RNA binding