Cit

Enables scaffold protein binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; gamma-aminobutyric acid signaling pathway; and postsynapse organization. Located in several cellular components, including GABA-ergic synapse; cleavage furrow; and postsynaptic density. Used to study epilepsy and microcephaly. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cit often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cit gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Cit gene, providing context for its role in the cell.