Mlc1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in caveolin-mediated endocytosis; cellular response to cholesterol; and protein transport. Located in several cellular components, including caveola; endosome; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 1. Orthologous to human MLC1 (modulator of VRAC current 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlc1 |
| Official Name | modulator of VRAC current 1 [Source:RGD Symbol;Acc:1308552] |
| Ensembl ID | ENSRNOG00000032871 |
| Bio databases IDs | |
| Aliases | modulator of VRAC current 1 |
| Synonyms | Kiaa0027-hp, LVM, megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human), MLC, modulator of VRAC current 1, VL, WKL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mlc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- neoplasia
- cancer
- megalencephalic leukoencephalopathy with subcortical cysts 1
- hereditary disorder
- megalencephalic leukoencephalopathy with subcortical cysts
- glioblastoma cancer
- familial catatonic schizophrenia
- Parkinson disease
regulates
role in cell
- expression in
- phosphorylation in
- formation
- function
- sphere formation
- abnormal morphology
- response by
- invasion by
- osmotic shock response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- endosomes
- lysosome
- Endoplasmic Reticulum
- intercellular junctions
- granules
- cytosol
- apical membrane
- caveolae
- basolateral membrane
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- endolysosomes
- membrane rafts
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mlc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of response to osmotic stress
- vesicle-mediated transport
- cellular response to cholesterol
- caveolin-mediated endocytosis
- protein transport
- positive regulation of intracellular transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- lysosome
- caveola
- early endosome
- perinuclear region of cytoplasm
- endosome
- cytoplasm
- membrane raft
- membrane
- cytosol
- cytoplasmic vesicle
- recycling endosome
- clathrin-coated vesicle
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding