Klhl24 Gene Summary [Rat]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intermediate filament organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in adherens junction and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and familial hypertrophic cardiomyopathy. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl24 |
| Official Name | kelch-like family member 24 [Source:RGD Symbol;Acc:727971] |
| Ensembl ID | ENSRNOG00000033372 |
| Bio databases IDs | |
| Aliases | kelch-like family member 24 |
| Synonyms | 1110046J11RIK, 4930429H24RIK, 6530402O20Rik, C85082, CMH29, DRE1, EBS6, EBSSH, FLJ20059, kelch-like 24, kelch-like family member 24, KRIP6, LOC339924 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klhl24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- glioblastoma
- glioblastoma cancer
- non-insulin-dependent diabetes mellitus
- generalized epidermolysis bullosa simplex with scarring and hair loss
- familial hypertrophic cardiomyopathy type 29 with polyglucosan bodies
- COVID-19
- generalized epidermolysis bullosa simplex
- osteoarthritis
- white matter hyperintensities
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- desmosomes
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klhl24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intermediate filament organization
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoplasm
- desmosome
- Cul3-RING ubiquitin ligase complex
- perikaryon
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding