Cib1 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade. Located in axon; dendrite; and neuronal cell body. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cib1 |
| Official Name | calcium and integrin binding 1 [Source:RGD Symbol;Acc:620133] |
| Ensembl ID | ENSRNOG00000033498 |
| Bio databases IDs | |
| Aliases | calcium and integrin binding 1 |
| Synonyms | calcium and integrin binding 1, Calcium and integrin bind. protein 1, CIB, Cibkip, CIBP, EV3, ISBP, KIP, KIP1, PRKDCIP, SIP2-28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cib1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- protein kinase binding
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- protein binding activity, bridging
- calcium ion binding
- enzyme binding
- EFh
- calcium-dependent protein kinase inhibitor activity
- protein binding
- EF-hand domain
- protein serine/threonine kinase inhibitor
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- ion channel binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- susceptibility to epidermodysplasia verruciformis type 3
- pressure overload hypertrophy
- androgenic alopecia
- organismal death
- severe COVID-19
role in cell
- number
- cell death
- proliferation
- apoptosis
- migration
- phosphorylation in
- quantity
- activation in
- differentiation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent-insoluble fractions
- membrane fraction
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- membrane ruffles
- plasma membrane extracellular face
- nuclear foci
- nucleoplasm
- nuclear bodies
- growth cone
- neurites
- sarcolemma
- filopodia
- perikaryon
- axons
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cib1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- endomitotic cell cycle
- extrinsic apoptotic signaling pathway
- cell adhesion
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of NF-kappaB transcription factor activity
- double-strand break repair
- cell division
- regulation of cell division
- positive regulation of cell growth
- response to ischemia
- angiogenesis
- negative regulation of neuron projection development
- apoptotic process
- positive regulation of male germ cell proliferation
- platelet formation
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of cell adhesion mediated by integrin
- cellular response to tumor necrosis factor
- spermatid development
- negative regulation of microtubule depolymerization
- thrombopoietin-mediated signaling pathway
- positive regulation of substrate adhesion-dependent cell spreading
- negative regulation of megakaryocyte differentiation
- response to DNA damage stimulus
- regulation of cell proliferation
- positive regulation of cell-matrix adhesion
- positive regulation of catalytic activity
- negative regulation of protein phosphorylation
- cellular response to growth factor stimulus
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cytoplasmic microtubule organization
- positive regulation of protein serine/threonine kinase activity
- negative regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- neuronal cell body
- perikaryon
- neuron projection
- plasma membrane
- nucleoplasm
- growth cone
- nucleus
- centrosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- sarcolemma
- membrane
- filopodium tip
- vesicle
- ruffle membrane
- axon
- apical plasma membrane
- lamellipodium
- cell periphery
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- protein anchor
- calcium ion binding
- small GTPase binding
- calcium-dependent protein kinase inhibitor activity
- ion channel binding