Tmc8 Gene Summary [Rat]
Predicted to enable mechanosensitive monoatomic ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Predicted to be involved in several processes, including intracellular zinc ion homeostasis; protein stabilization; and regulation of signal transduction. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmc8 |
| Official Name | transmembrane channel-like 8 [Source:RGD Symbol;Acc:1591150] |
| Ensembl ID | ENSRNOG00000046086 |
| Bio databases IDs | |
| Aliases | transmembrane channel-like 8 |
| Synonyms | EV2, EVER2, EVIN2, mFLJ00400, transmembrane channel-like 8, transmembrane channel-like gene family 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmc8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
- cytokine binding
- protein binding
- transmembrane channel domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epidermodysplasia verruciformis
- diabetic nephropathy
- organismal death
- susceptibility to epidermodysplasia verruciformis type 2
- susceptibility to epidermodysplasia verruciformis type 1
- diabetes mellitus
- hemolysis
- cervical intraepithelial neoplasia
role in cell
- expression in
- apoptosis
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmc8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- cellular zinc ion homeostasis
- negative regulation of protein complex assembly
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- mechanically-gated ion channel activity
- protein binding
- tumor necrosis factor binding