Sgk2 Gene Summary [Rat]
Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgk2 |
| Official Name | serum/glucocorticoid regulated kinase 2 [Source:RGD Symbol;Acc:620232] |
| Ensembl ID | ENSRNOG00000033573 |
| Bio databases IDs | |
| Aliases | serum/glucocorticoid regulated kinase 2 |
| Synonyms | dJ138B7.2, H-SGK2, Serum/glucocorticoid regulated kinase 2, Sgkl |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- sodium channel regulator
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- myeloproliferative neoplasm
- myeloproliferative disorder
- colon cancer
regulates
role in cell
- proliferation
- growth
- stabilization in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- regulation of cell growth
- positive regulation of transporter activity
- peptidyl-serine phosphorylation
- protein phosphorylation
- regulation of cell proliferation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- potassium channel regulator activity