SGK2 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | SGK2 |
| Official Name | serum/glucocorticoid regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:13900] |
| Ensembl ID | ENSG00000101049 |
| Bio databases IDs | |
| Aliases | serum/glucocorticoid regulated kinase 2 |
| Synonyms | dJ138B7.2, H-SGK2, Serum/glucocorticoid regulated kinase 2, Sgkl |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- sodium channel regulator
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- myeloproliferative neoplasm
- myeloproliferative disorder
- colon cancer
regulates
role in cell
- proliferation
- growth
- stabilization in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- regulation of cell growth
- positive regulation of transporter activity
- peptidyl-serine phosphorylation
- protein phosphorylation
- regulation of cell proliferation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- potassium channel regulator activity