Fkbp5 Gene Summary [Rat]
Predicted to enable heat shock protein binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein-macromolecule adaptor activity. Involved in response to alcohol and response to cocaine. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Biomarker of alcohol dependence and cocaine abuse. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp5 |
| Official Name | FKBP prolyl isomerase 5 [Source:RGD Symbol;Acc:1309155] |
| Ensembl ID | ENSRNOG00000022523 |
| Bio databases IDs | |
| Aliases | FKBP prolyl isomerase 5 |
| Synonyms | AIG6, D17Ertd592e, Dit1, FK506 binding protein 5, FKBP51, FKBP54, FKBP prolyl isomerase 5, P54, PPIase, Ptg-10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fkbp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- FK506 binding
- heat shock protein binding
- protein binding activity, bridging
- Tetratricopeptide repeats
- calmodulin binding domain
- enzyme
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Fkbp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- liver cancer
- idiopathic pulmonary fibrosis
- hepatic steatosis
- Parkinson disease
- coronary artery disease
- diabetes mellitus
- rheumatoid arthritis
- osteoarthritis
- Alzheimer disease
role in cell
- expression in
- activation in
- phosphorylation in
- proliferation
- apoptosis
- growth
- survival
- outgrowth
- upregulation in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fkbp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- chaperone-mediated protein folding
- protein peptidyl-prolyl isomerization
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- FK506 binding
- protein binding, bridging