AABR07024769.1 Gene Summary [Rat]
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | AABR07024769.1 |
| Official Name | neuregulin 3 [Source:NCBI gene;Acc:498596] |
| Ensembl ID | ENSRNOG00000033894 |
| Bio databases IDs | |
| Aliases | neuregulin 3 |
| Synonyms | AI413391, HRG3, neuregulin 3, pro-NRG3, RGD1559678, SKA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07024769.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemorepellant
- receptor agonist activity
- protein binding
- EGF-like domain
- growth factor
Pathways
Biological processes and signaling networks where the Aabr07024769.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- acute myeloid leukemia
- colorectal cancer
- plasma cell myeloma
- insomnia
- Epstein-Barr virus infection
- bipolar disorder
- disorder of jaw region
- eating disorder
- breast carcinoma
role in cell
- proliferation
- growth
- development
- assembly
- migration by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07024769.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- mammary placode formation
- ERBB4-ERBB4 signaling pathway
- regulation of cell growth
- pattern specification process
- chemorepulsion involved in interneuron migration from the subpallium to the cortex
- regulation of synaptic transmission
- ERBB4 signaling pathway
- organ development
- intracellular signal transduction
- negative regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- transmembrane receptor protein tyrosine kinase activator activity
- receptor agonist activity
- chemorepellent activity
- receptor tyrosine kinase binding