Erbb4 Gene Summary [Rat]
Enables neuregulin receptor activity. Involved in several processes, including cellular response to L-glutamate; modulation of chemical synaptic transmission; and nervous system development. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Is active in plasma membrane. Used to study status epilepticus. Biomarker of several diseases, including amblyopia; bipolar disorder; interstitial cystitis; median neuropathy; and radiculopathy. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erbb4 |
| Official Name | erb-b2 receptor tyrosine kinase 4 [Source:RGD Symbol;Acc:620486] |
| Ensembl ID | ENSRNOG00000014248 |
| Bio databases IDs | |
| Aliases | erb-b2 receptor tyrosine kinase 4 |
| Synonyms | ALS19, C-erb-b4, erb-b2 receptor tyrosine kinase 4, HER4, p180erbB4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Erbb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Furin-like cysteine rich region
- TM_EGFR-like
- protein-tyrosine kinase
- Protein kinase domain
- FU
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- tail domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Growth factor receptor domain IV
- nucleic acid binding
- PPXY motif
- Protein tyrosine and serine/threonine kinase
- epidermal growth factor receptor binding
- ectodomain
- protein binding
- receptor binding
- epidermal growth factor receptor
- sequence-specific DNA binding
- proline tyrosine motif
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Receptor L domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- double-stranded DNA binding
- membrane attachment signal
- transmembrane domain
- tyrosine kinase domain
- Furin-like repeats
- protein homodimerization
- cytosolic tail domain
- PDZ binding motif
- substrate binding domain
Pathways
Biological processes and signaling networks where the Erbb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- non-insulin-dependent diabetes mellitus
- metastatic large cell lung carcinoma
- advanced non-small cell lung cancer
- advanced large cell lung carcinoma
- metastatic non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- metastatic lung adenocarcinoma
- epithelial cancer
role in cell
- production in
- apoptosis
- expression in
- cell viability
- quantity
- survival
- loss
- loss in
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- cholinergic bouton
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Mitochondria
- cytosol
- apical cell surfaces
- presynaptic membrane
- postsynaptic membrane
- caveolae
- synaptic membrane
- basolateral membrane
- mitochondrial matrix
- nucleoplasm
- perinuclear space
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- neurites
- synaptosomes
- synapse
- cytoplasmic vesicles
- rough endoplasmatic reticulum
- transverse tubules
- membrane rafts
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- neuromuscular synapse
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Erbb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERBB2-ERBB4 signaling pathway
- peptidyl-tyrosine phosphorylation
- positive regulation of cardiac muscle cell proliferation
- ERBB4-ERBB4 signaling pathway
- multicellular organismal development
- negative regulation of cell proliferation
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- nervous system development
- protein autophosphorylation
- lactation
- neurogenesis
- ERBB4 signaling pathway
- positive regulation of tyrosine phosphorylation of STAT protein
- central nervous system morphogenesis
- mammary gland epithelial cell differentiation
- JAK-STAT cascade
- heart development
- mammary gland alveolus development
- positive regulation of transcription, DNA-dependent
- establishment of planar polarity involved in nephron morphogenesis
- positive regulation of kinase activity
- cell migration
- cardiac muscle tissue regeneration
- positive regulation of protein localization at cell surface
- olfactory bulb interneuron differentiation
- signal transduction
- embryonic pattern specification
- transmembrane receptor protein tyrosine kinase signaling pathway
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of JAK-STAT cascade
- synapse assembly
- neural crest cell migration
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- cellular response to epidermal growth factor stimulus
- cell fate commitment
- positive regulation of ERK1 and ERK2 cascade
- regulation of cell migration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- receptor complex
- extracellular region
- plasma membrane
- nucleoplasm
- nucleus
- basal plasma membrane
- postsynaptic membrane
- mitochondrial matrix
- mitochondrion
- cytosol
- neuromuscular junction
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein homodimerization activity
- transmembrane receptor protein tyrosine kinase activity
- neuregulin receptor activity
- epidermal growth factor receptor binding
- transcription regulatory region sequence-specific DNA binding
- GABA receptor binding
- epidermal growth factor-activated receptor activity