Nrg3 Gene Summary [Mouse]
Enables chemorepellent activity. Involved in ERBB4-ERBB4 signaling pathway and synapse assembly. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Is active in extracellular space and glutamatergic synapse. Is expressed in several structures, including embryo mesenchyme; epidermis; mammary gland primordium; nervous system; and testis. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrg3 |
| Official Name | neuregulin 3 [Source:MGI Symbol;Acc:MGI:1097165] |
| Ensembl ID | ENSMUSG00000041014 |
| Bio databases IDs | |
| Aliases | neuregulin 3 |
| Synonyms | AI413391, HRG3, neuregulin 3, pro-NRG3, RGD1559678, SKA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemorepellant
- receptor agonist activity
- protein binding
- EGF-like domain
- growth factor
Pathways
Biological processes and signaling networks where the Nrg3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- acute myeloid leukemia
- colorectal cancer
- plasma cell myeloma
- insomnia
- Epstein-Barr virus infection
- bipolar disorder
- disorder of jaw region
- eating disorder
- breast carcinoma
role in cell
- proliferation
- growth
- development
- assembly
- migration by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- mammary placode formation
- ERBB4-ERBB4 signaling pathway
- regulation of cell growth
- pattern specification process
- chemorepulsion involved in interneuron migration from the subpallium to the cortex
- regulation of synaptic transmission
- ERBB4 signaling pathway
- organ development
- intracellular signal transduction
- negative regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- transmembrane receptor protein tyrosine kinase activator activity
- receptor agonist activity
- chemorepellent activity
- receptor tyrosine kinase binding