Ago3 Gene Summary [Rat]
Predicted to enable RNA binding activity and endoribonuclease activity, cleaving miRNA-paired mRNA. Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction; regulation of gene expression; and regulation of stem cell proliferation. Predicted to be located in condensed nuclear chromosome; cytosol; and nucleoplasm. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human AGO3 (argonaute RISC catalytic component 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ago3 |
| Official Name | argonaute RISC catalytic component 3 [Source:RGD Symbol;Acc:1309163] |
| Ensembl ID | ENSRNOG00000034269 |
| Bio databases IDs | |
| Aliases | argonaute RISC catalytic component 3 |
| Synonyms | argonaute RISC catalytic component 3, argonaute RISC catalytic subunit 3, C130014L07Rik, EIF2C3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ago3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Argonaute linker 2 domain
- Piwi-like
- N-terminal domain of argonaute
- PAZ domain
- protein binding
- 5' phosphomonoester producing endoribonuclease
- single-stranded RNA binding
- Piwi domain
- translation regulator
- RNA binding
- Mid domain of argonaute
- Argonaute linker 1 domain
- double-stranded RNA binding
- endoribonuclease
- PAZ
Pathways
Biological processes and signaling networks where the Ago3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- Barrett syndrome
role in cell
- apoptosis
- growth
- expression in
- proliferation
- differentiation
- RNA post-transciptional gene silencing in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic ribonucleoprotein granule
- cytosol
- chromosome
- sister chromatids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ago3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- posttranscriptional gene silencing by RNA
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- positive regulation of gene expression
- RNA secondary structure unwinding
- regulation of stem cell proliferation
- small RNA loading onto RISC
- mRNA cleavage involved in gene silencing by miRNA
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- RISC-loading complex
- cytosol
- cytoplasmic mRNA processing body
- RNA-induced silencing complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- RNA binding
- protein binding
- double-stranded RNA binding
- metal ion binding
- single-stranded RNA binding
- endoribonuclease activity