Pum1 Gene Summary [Rat]
Predicted to enable mRNA 3'-UTR binding activity and miRNA binding activity. Predicted to be involved in several processes, including adult locomotory behavior; positive regulation of RIG-I signaling pathway; and regulation of gene expression. Predicted to act upstream of or within post-transcriptional regulation of gene expression. Located in axon. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to human PUM1 (pumilio RNA binding family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pum1 |
| Official Name | pumilio RNA-binding family member 1 [Source:RGD Symbol;Acc:1307190] |
| Ensembl ID | ENSRNOG00000011709 |
| Bio databases IDs | |
| Aliases | pumilio RNA-binding family member 1 |
| Synonyms | HSPUM, mKIAA0099, NEDMSF, PUMH, PUMH1, pumilio RNA-binding family member 1, PUML1, Pumm, SCA47 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pum1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pumilio-like repeats
- mRNA 3' UTR binding
- Pumilio-family RNA binding domain
- Pumilio-family RNA binding repeat
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- metabolic syndrome X
- tumorigenesis
- colorectal cancer
- hereditary spastic ataxia
- early-onset spinocerebellar ataxia 47
- pumilio 1 associated developmental disability, ataxia and seizure syndrome
- hypoplasia
- oligozoospermia
role in cell
- proliferation
- activation in
- expression in
- differentiation
- apoptosis
- growth
- cell cycle progression
- production
- G1/S phase transition
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- nucleoplasm
- stress granule
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pum1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA destabilization
- 3'-UTR-mediated mRNA destabilization
- spermatogenesis
- production of miRNAs involved in gene silencing by miRNA
- regulation of mRNA stability
- adult locomotory behavior
- positive regulation of RIG-I signaling pathway
- regulation of gene silencing by miRNA
- regulation of chromosome segregation
- posttranscriptional regulation of gene expression
- regulation of translation
- stem cell differentiation
- positive regulation of gene silencing by miRNA
- posttranscriptional gene silencing
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein binding
- RNA binding
- mRNA 3'-UTR binding