Acer3 Gene Summary [Rat]
Predicted to enable N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acer3 |
| Official Name | alkaline ceramidase 3 [Source:RGD Symbol;Acc:1561254] |
| Ensembl ID | ENSRNOG00000036866 |
| Bio databases IDs | |
| Aliases | alkaline ceramidase 3 |
| Synonyms | 1110057L18Rik, 5430429L08Rik, alkaline ceramidase 3, APHC, PHCA, PLDECO, RGD1561254 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acer3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- calcium ion binding
- enzyme
- ceramidase
Pathways
Biological processes and signaling networks where the Acer3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute graft-vs-host disease
- early childhood-onset progressive leukodystrophy
regulated by
- Zn2+
- Ca2+
- ASAH1
- D-sphingosine
role in cell
- expression in
- proliferation
- apoptosis
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acer3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- positive regulation of cell proliferation
- sphingosine biosynthetic process
- regulation of programmed cell death
- myelination
- ceramide catabolic process
- phytosphingosine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ceramidase activity
- calcium ion binding
- dihydroceramidase activity
- phytoceramidase activity