Acer2 Gene Summary [Rat]
Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of cell adhesion; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Orthologous to human ACER2 (alkaline ceramidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acer2 |
| Official Name | alkaline ceramidase 2 [Source:RGD Symbol;Acc:1304629] |
| Ensembl ID | ENSRNOG00000007637 |
| Bio databases IDs | |
| Aliases | alkaline ceramidase 2 |
| Synonyms | 2410116I05RIK, alkaline ceramidase 2, ALKCDase2, ASAH3L, C230070D10Rik, CRG-L1, maCER2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acer2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- ceramidase
Pathways
Biological processes and signaling networks where the Acer2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MEX3A
- MPP1
disease
- coronary artery disease
- diabetes mellitus
role in cell
- cell viability
- apoptosis
- cell death
- proliferation
- adhesion
- autophagy by
- glycosylation in
- generation in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acer2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- sphingosine biosynthetic process
- regulation of apoptotic process
- response to DNA damage stimulus
- regulation of protein glycosylation
- ceramide catabolic process
- negative regulation of cell adhesion mediated by integrin
- response to retinoic acid
- negative regulation of cell-matrix adhesion
- regulation of autophagy
- DNA damage response, signal transduction by p53 class mediator
- cellular response to xenobiotic stimulus
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ceramidase activity
- metal ion binding
- dihydroceramidase activity