Svip Gene Summary [Rat]
Predicted to enable ATPase binding activity. Involved in negative regulation of ERAD pathway; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; and negative regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SVIP (small VCP interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Svip |
| Official Name | small VCP interacting protein [Source:RGD Symbol;Acc:1565432] |
| Ensembl ID | ENSRNOG00000037137 |
| Bio databases IDs | |
| Aliases | small VCP interacting protein |
| Synonyms | 1700006C13Rik, 6620401M08Rik, RGD1565432, small VCP interacting protein, small VCP/p97-interacting protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Svip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- Small VCP/p97-interacting protein
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- breast cancer
- HER2 negative hormone receptor negative breast cancer
- sensorineural hearing loss
- luminal B breast cancer
- chronic kidney disease
- HER2-positive breast cancer
- luminal A breast cancer
regulates
- protein-protein complex
- VLDL
role in cell
- formation
- formation in
- migration
- morphology
- proliferation
- autophagy by
- vacuolation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- tertiary granule membrane
- cytosol
- endoplasmic reticulum membrane
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Svip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- negative regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- secretory granule membrane
- smooth endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- Golgi membrane
- plasma membrane
- tertiary granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase binding