Ckap5 Gene Summary [Rat]
Predicted to enable microtubule binding activity; microtubule plus end polymerase; and ribonucleoprotein complex binding activity. Predicted to be involved in microtubule cytoskeleton organization and positive regulation of microtubule nucleation. Predicted to act upstream of or within several processes, including central nervous system myelin formation; dendritic spine maintenance; and learning. Predicted to be located in several cellular components, including microtubule cytoskeleton; neuronal ribonucleoprotein granule; and perikaryon. Predicted to be part of protein-containing complex. Predicted to be active in centrosome; kinetochore; and spindle pole. Predicted to colocalize with microtubule plus-end. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ckap5 |
| Official Name | cytoskeleton associated protein 5 [Source:RGD Symbol;Acc:1563596] |
| Ensembl ID | ENSRNOG00000016067 |
| Bio databases IDs | |
| Aliases | cytoskeleton associated protein 5 |
| Synonyms | 3110043H24Rik, 4930432B04RIK, CHTOG, cytoskeleton associated protein 5, D730027C18RIK, mKIAA0097, MSPS, TOG, TOGP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ckap5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- transcription regulator
- ribonucleoprotein binding
- protein binding
Pathways
Biological processes and signaling networks where the Ckap5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chromosomal instability
- breast cancer
- venous thromboembolism
- polycystic ovary syndrome
role in cell
- apoptosis
- assembly
- cell viability
- formation
- formation in
- maintenance
- regrowth
- growth
- fragmentation
- catastrophe
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule aster fraction
- microtubule cytoskeleton
- dendritic growth cone
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- microtubules
- cytosol
- nucleoli
- spindle pole
- neurites
- mitotic spindle
- kinetochores
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ckap5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle organization
- centrosome cycle
- centrosome duplication
- mitotic spindle organization
- RNA transport
- positive regulation of microtubule nucleation
- microtubule polymerization
- microtubule depolymerization
- establishment or maintenance of microtubule cytoskeleton polarity
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule cytoskeleton
- cytoplasm
- microtubule plus end
- membrane
- spindle pole
- cytosol
- macromolecular complex
- kinetochore
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- ribonucleoprotein complex binding
- microtubule plus-end binding
- microtubule binding