Spag17 Gene Summary [Rat]
Predicted to be involved in cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and spermatid development. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in Golgi apparatus; acrosomal vesicle; and manchette. Predicted to be active in axonemal central apparatus. Human ortholog(s) of this gene implicated in spermatogenic failure 55. Orthologous to human SPAG17 (sperm associated antigen 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spag17 |
| Official Name | sperm associated antigen 17 [Source:RGD Symbol;Acc:1592218] |
| Ensembl ID | ENSRNOG00000037196 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 17 |
| Synonyms | 4931427F14Rik, CT143, LOC100048815, LOC100911866, PF6, Spag17-ps, sperm associated antigen 17, SPGF55 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spag17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar-associated PapD-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilic esophagitis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hydrocephalus
- breast carcinoma
- pulmonary edema
- atelectasis
- respiratory failure
- dyspnea
phenotypes
- Short Stature Idiopathic Autosomal
- Idiopathic Short Stature Autosomal
role in cell
- assembly
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- manchette
- Golgi Apparatus
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spag17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- epithelial cilium movement
- motile cilium assembly
Cellular Component
Where in the cell the gene product is active
- motile cilium
- acrosomal vesicle
- Golgi apparatus
- extracellular region
- manchette
- microtubule