Fbxo44 Gene Summary [Rat]
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo44 |
| Official Name | F-box protein 44 [Source:RGD Symbol;Acc:1562463] |
| Ensembl ID | ENSRNOG00000009298 |
| Bio databases IDs | |
| Aliases | F-box protein 44 |
| Synonyms | 5730411K09, FBG3, F-box protein 44, F-box protein FBX30, FBX30, Fbx44, FBX6A, Fbxo6a, RGD1562463 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- F-box associated region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- gastroesophageal junction adenocarcinoma
- esophagogastric junction cancer
- neoplasia
- gastrointestinal neoplasia
regulated by
- MEF2A
- EED226
- ocifisertib
- OSMI-1
role in cell
- expression in
- proliferation
- replication in
- apoptosis
- sphere formation
- invasion by
- migration
- downregulation in
- recruitment in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding