Hars1 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hars1 |
| Official Name | histidyl-tRNA synthetase 1 [Source:RGD Symbol;Acc:1310695] |
| Ensembl ID | ENSRNOG00000028105 |
| Bio databases IDs | |
| Aliases | histidyl-tRNA synthetase 1 |
| Synonyms | CMT2W, Dnd1, HARS, Histidyl-tRNA synthetase, histidyl-tRNA synthetase 1, HRS, MMHRS, USH3B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hars1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histidine-tRNA ligase
- HGTP_anticodon
- class_II_aaRS-like_core
- histidyl-tRNA synthetase
- S15_NS1_EPRS_RNA-bind
- ATP binding
- ATP phosphoribosyltransferase, regulatory subunit
- enzyme
- identical protein binding
- WHEP-TRS domain
- Anticodon binding domain
- protein homodimerization
- WHEP-TRS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Usher syndrome type 3
- hereditary spastic ataxia
- axonal Charcot-Marie-Tooth disease type 2W
- myositis
- Usher syndrome type IIIB
- hereditary disorder
- peripheral neuropathy
role in cell
- activation in
- migration
- signaling in
- cellular infiltration
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hars1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- histidyl-tRNA aminoacylation
- mitochondrial translation
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- histidine-tRNA ligase activity
- ATP binding
- identical protein binding
- protein homodimerization activity
- RNA binding