Hspa1l Gene Summary [Rat]
Predicted to enable several functions, including ATP hydrolysis activity; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding; positive regulation of protein targeting to mitochondrion; and protein refolding. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in Kawasaki disease; major depressive disorder; schizophrenia; systemic lupus erythematosus; and uveitis. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa1l |
| Official Name | heat shock protein family A (Hsp70) member 1 like [Source:RGD Symbol;Acc:1595925] |
| Ensembl ID | ENSRNOG00000047966 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 1 like |
| Synonyms | heat shock protein 1-like, heat shock protein family A (Hsp70) member 1 like, Hsc70t, HSP70-1L, Hsp70-3, HSP70-HOM, HSP70T, hum70t, Msh5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspa1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fe-S protein assembly chaperone HscA
- ubiquitin protein ligase binding
- MreB/Mbl protein
- Cell division protein FtsA
- heat shock protein binding
- chaperone protein DnaK
- protein binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa1l gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Crohn disease
- epileptic seizure
- insulin-dependent diabetes mellitus
- Parkinson disease
- irritable bowel syndrome
- hypersensitive reaction
- plantar wart
role in cell
- binding
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- perikaryon
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspa1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone mediated protein folding requiring cofactor
- protein refolding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
- cell body
- blood microparticle
- cytosol
- signalosome
- sperm protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- heat shock protein binding
- ubiquitin protein ligase binding
- protein binding involved in protein folding
- protein binding
- unfolded protein binding