Ap1s2 Gene Summary [Rat]
Predicted to enable clathrin adaptor activity. Predicted to be involved in synaptic vesicle budding from endosome. Predicted to act upstream of or within several processes, including adipose tissue development; fat cell differentiation; and visual learning. Predicted to be located in Golgi apparatus. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 5. Orthologous to human AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap1s2 |
| Official Name | adaptor related protein complex 1 subunit sigma 2 [Source:RGD Symbol;Acc:1561862] |
| Ensembl ID | ENSRNOG00000038686 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 1 subunit sigma 2 |
| Synonyms | 1500012A13Rik, adaptor-related protein complex 1, sigma 2 subunit, adaptor related protein complex 1 subunit sigma 2, adaptor related protein complex 1 subunit σ 2, adaptor-related protein complex 1, σ 2 subunit, AP1B, DC22, EST1, MRX59, MRXS21, MRXS5, MRXSF, PGS, RGD1561862, SIGMA1B, Sigma2 adaptin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap1s2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA binding domain
- Clathrin adaptor complex small chain
- APS2
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap1s2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- COVID-19
- Parkinson disease
- Pettigrew syndrome
- X-linked mental retardation
- syndromic X-linked mental retardation
- Turner syndrome
role in cell
- motility
- differentiation
- migration
- budding
- linkage
- budding in
- linkage in
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- vesicles
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- lysosome membrane
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap1s2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- early endosome
- AP-type membrane coat adaptor complex
- coated pit
- intracellular membrane-bounded organelle
- AP-1 adaptor complex
- cytosol
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin adaptor activity