Rab9a Gene Summary [Rat]
Predicted to enable G protein activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of exocytosis; receptor-mediated endocytosis; and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasmic vesicle membrane and melanosome. Predicted to be active in late endosome; lysosome; and phagocytic vesicle. Orthologous to human RAB9A (RAB9A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab9a |
| Official Name | RAB9A, member RAS oncogene family [Source:RGD Symbol;Acc:619740] |
| Ensembl ID | ENSRNOG00000030443 |
| Bio databases IDs | |
| Aliases | RAB9A, member RAS oncogene family |
| Synonyms | 2410064E05Rik, RAB9, RAB9A, member RAS oncogene family, RAB9, member RAS oncogene family, Sid6061p |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- alpha helix
- GTPase
- enzyme
- protein binding
- identical protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- trafficking in
- formation
- quantity
- size
- exocytosis by
- replication in
- macroautophagy in
- transport
- vacuolation
- secretion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- cytosol
- trans Golgi network
- growth cone
- late endosomes
- transport vesicles
- melanosomes
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- phagosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- protein transport
- Rab protein signal transduction
- retrograde transport, endosome to Golgi
- negative regulation by host of symbiont catalytic activity
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- late endosome
- phagocytic vesicle
- Golgi membrane
- plasma membrane
- lysosome
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- melanosome
- cytosol
- phagocytic vesicle membrane
- transport vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding