AABR07037410.1 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in several cellular components, including Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in X-linked Aarskog syndrome and non-syndromic X-linked intellectual disability. Orthologous to human FGD1 (FYVE, RhoGEF and PH domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | AABR07037410.1 |
| Official Name | FYVE, RhoGEF and PH domain containing 1 [Source:NCBI gene;Acc:363460] |
| Ensembl ID | ENSRNOG00000038970 |
| Bio databases IDs | |
| Aliases | FYVE, RhoGEF and PH domain containing 1 |
| Synonyms | AAS, FGDY, FYVE, RhoGEF and PH domain containing 1, LOC102555067, LOC108348117, MRXS16, ZFYVE3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07037410.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
- RhoGEF domain
- FYVE domain like superfamily
- RhoGEF
- Protein present in Fab1, YOTB, Vac1, and EEA1
- guanyl-nucleotide exchange factor
- PH domain
- PHD finger superfamily
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Aabr07037410.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Aarskog-Scott syndrome with attention deficit-hyperactivity disorder
- mental retardation
- hereditary disorder
- Aarskog-Scott syndrome
- syndromic x-linked mental retardation type 16
- nonsyndromic X-linked mental retardation
role in cell
- migration
- invasion by
- activation in
- cell viability
- formation
- stimulation
- polarization
- morphology
- assembly
- polarization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cellular membrane
- actin cytoskeleton
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07037410.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- signal transduction
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- filopodium assembly
- actin cytoskeleton organization
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- ruffle
- cytosol
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding