Pabpn1 Gene Summary [Rat]
Predicted to enable RNA polymerase binding activity and poly(A) binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; poly(A)+ mRNA export from nucleus; and positive regulation of polynucleotide adenylyltransferase activity. Located in nuclear inclusion body. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pabpn1 |
| Official Name | poly(A) binding protein, nuclear 1 [Source:RGD Symbol;Acc:619928] |
| Ensembl ID | ENSRNOG00000042195 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein, nuclear 1 |
| Synonyms | mPABII, OPMD, PAB2, PABII, PABN1, PABP-2, Pabp3, poly(A) binding protein nuclear 1, poly(A) binding protein, nuclear 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pabpn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- enzyme binding
- poly(A) binding protein
- enzyme
- protein binding
- identical protein binding
- polyalanine repeat
- RNA binding
Pathways
Biological processes and signaling networks where the Pabpn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- oculopharyngeal muscular dystrophy type 1
- oculopharyngeal muscular dystrophy
- hereditary disorder
- dysphagia
- hepatoblastoma
role in cell
- expression in
- apoptosis
- proliferation
- formation
- fusion
- migration
- binding in
- damage in
- autophagy in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- spliceosomes
- nuclear foci
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pabpn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to lipopolysaccharide
- muscle contraction
- RNA processing
- mRNA processing
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear inclusion body
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- RNA binding
- protein binding
- poly(A) RNA binding