Ephb4 Gene Summary [Rat]
Predicted to enable ephrin receptor activity. Predicted to be involved in several processes, including circulatory system development; ephrin receptor signaling pathway; and protein autophosphorylation. Predicted to act upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in central conducting lymphatic anomaly. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ephb4 |
| Official Name | EPH receptor B4 [Source:RGD Symbol;Acc:1583193] |
| Ensembl ID | ENSRNOG00000045952 |
| Bio databases IDs | |
| Aliases | EPH receptor B4 |
| Synonyms | b2b2412Clo, CMAVM2, EPH receptor B4, Ephrin b4, HFASD, HTK, LMPHM7, MDK2, MYK1, TYRO11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ephb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ectodomain
- ephrin receptor
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- FN3
- transmembrane domain
- SAM domain (Sterile alpha motif)
- cytosolic tail domain
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Ephb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- hypotension
- Alzheimer disease
- capillary malformation-arteriovenous malformation 2
- Takayasu arteritis
- Crohn disease
- hereditary lymphedema type I
- non-small cell lung carcinoma
role in cell
- expression in
- growth
- cell death
- survival
- quantity
- apoptosis
- invasion by
- phosphorylation in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ephb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart morphogenesis
- multicellular organismal development
- angiogenesis
- ephrin receptor signaling pathway
- protein autophosphorylation
- positive regulation of kinase activity
- cell migration involved in sprouting angiogenesis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- ephrin receptor activity