Ebp Gene Summary [Rat]
Enables C-8 sterol isomerase activity. Involved in cholesterol biosynthetic process. Predicted to be located in nuclear membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in MEND syndrome; X-linked chondrodysplasia punctata 2; and chondrodysplasia punctata. Orthologous to human EBP (EBP cholestenol delta-isomerase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ebp |
| Official Name | EBP, cholestenol delta-isomerase [Source:RGD Symbol;Acc:620957] |
| Ensembl ID | ENSRNOG00000004903 |
| Bio databases IDs | |
| Aliases | EBP, cholestenol delta-isomerase |
| Synonyms | CDPX2, CHO2, CPX, CPXD, D8D7I, EBP cholestenol delta-isomerase, EBP, cholestenol delta-isomerase, EBP cholestenol δ-isomerase, EBP, cholestenol δ-isomerase, Emopamil Binding, MEND, mSI, Pabp, SI, Td |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ebp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane 6 superfamily member 1, member 2, and similar proteins
- cholestenol D-isomerase
- C-8 sterol isomerase
- steroid D-isomerase
- enzyme
- protein binding
- ether hydrolase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- organismal death
- X-linked dominant chondrodysplasia punctata
- Alzheimer disease
- major depression
- COVID-19
- colon carcinoma
- colon epithelial cancer
- MEND syndrome
- atypical X-linked dominant chondrodysplasia punctata
regulates
- cholesterol
- tamoxifen
- sterol
role in cell
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ebp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol biosynthetic process via lathosterol
- hemopoiesis
- cholesterol biosynthetic process via desmosterol
- cholesterol metabolic process
- cholesterol biosynthetic process
- ossification involved in bone maturation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- nuclear membrane
- cytoplasmic vesicle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- steroid delta-isomerase activity
- cholestenol delta-isomerase activity
- C-8 sterol isomerase activity