Trmt10c Gene Summary [Rat]
Predicted to enable identical protein binding activity; tRNA binding activity; and tRNA methyltransferase activity. Predicted to be involved in RNA processing and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial nucleoid. Predicted to be part of mitochondrial ribonuclease P complex and tRNA methyltransferase complex. Predicted to be active in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 30. Orthologous to human TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trmt10c |
| Official Name | tRNA methyltransferase 10C, mitochondrial RNase P subunit [Source:RGD Symbol;Acc:1306333] |
| Ensembl ID | ENSRNOG00000039567 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase 10C, mitochondrial RNase P subunit |
| Synonyms | 1300018J16Rik, COXPD30, D16Ertd454e, HNYA, MRPP1, RG9MTD1, Rnmtd1, tRNA methyltransferase 10C, mitochondrial RNase P subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trmt10c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- tRNA (adenine)-methyltransferase
- tRNA (guanine) methyltransferase
- SPOUT superfamily of SAM-dependent RNA methyltransferases
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- combined oxidative phosphorylation deficiency 30
regulated by
- TCF4
- mir-21 (includes others)
role in cell
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trmt10c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mitochondrial translation
- mitochondrial RNA 5'-end processing
- mRNA processing
- mitochondrial tRNA methylation
Cellular Component
Where in the cell the gene product is active
- tRNA methyltransferase complex
- mitochondrial ribonuclease P complex
- nucleus
- mitochondrial matrix
- mitochondrion
- nucleoplasm
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- tRNA (guanine(9)-N(1))-methyltransferase activity
- tRNA binding