Cldn12 Gene Summary [Rat]
Predicted to be located in lateral plasma membrane and tight junction. Predicted to be active in plasma membrane. Orthologous to human CLDN12 (claudin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn12 |
| Official Name | claudin 12 [Source:RGD Symbol;Acc:1561053] |
| Ensembl ID | ENSRNOG00000039862 |
| Bio databases IDs | |
| Aliases | claudin 12 |
| Synonyms | claudin 12, RGD1561053 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular loop
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cldn12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
- intercellular junctions
- lateral plasma membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- tight junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding