Khsrp Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including miRNA metabolic process; negative regulation of low-density lipoprotein particle clearance; and regulation of biosynthetic process. Predicted to act upstream of or within mRNA catabolic process and regulation of miRNA metabolic process. Located in dendrite and neuronal cell body. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Khsrp |
| Official Name | KH-type splicing regulatory protein [Source:RGD Symbol;Acc:621828] |
| Ensembl ID | ENSRNOG00000047628 |
| Bio databases IDs | |
| Aliases | KH-type splicing regulatory protein |
| Synonyms | 6330409F21Rik, FBP2, FUBP2, KH-type splicing regulatory protein, KSRP, MARTA1, p75 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Khsrp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- mRNA binding
- enzyme
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- metastasis
- organismal death
- rheumatoid arthritis
- pancreatic epithelial cancer
- cutaneous melanoma cancer
- breast cancer
- neoplasia
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
role in cell
- activation in
- expression in
- phosphorylation in
- growth
- association
- invasion by
- maturation in
- accumulation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- perinucleolar compartments
- nucleoplasm
- interchromatin granule clusters
- stress granule
- perikaryon
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Khsrp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of mRNA catabolic process
- 3'-UTR-mediated mRNA destabilization
- regulation of mRNA stability
- mRNA processing
- protein folding
- negative regulation of nitric oxide biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- RNA splicing, via transesterification reactions
- negative regulation of low-density lipoprotein particle clearance
- cellular response to cytokine stimulus
- mRNA transport
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding involved in protein folding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- mRNA binding