LOC108348062 Gene Summary [Rat]
Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348062 |
| Official Name | eukaryotic translation initiation factor 3 subunit H [Source:RGD Symbol;Acc:11498408] |
| Ensembl ID | ENSRNOG00000040153 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit H |
| Synonyms | 1110008A16Rik, 9430017H16Rik, EIF3-gamma, EIF3-P40, eIF3 p40 subunit, EIF3S3, EIF3-γ, eukaryotic translation initiation factor 3 subunit H, eukaryotic translation initiation factor 3, subunit H, LOC108348062 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348062 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal region of eIF3h
- metallopeptidase
- Mpr1p, Pad1p N-terminal (MPN) domains
- translation initiation factor
- enzyme
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Loc108348062 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- metastasis
- epithelial cancer
- breast carcinoma
- organismal death
- non-small cell lung cancer
- hepatocellular carcinoma
- liver cancer
- abdominal aortic aneurysm
role in cell
- proliferation
- migration
- phosphorylation in
- expression in
- apoptosis
- invasion by
- growth
- binding in
- synthesis in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- multicilium
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348062 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- translational initiation
- regulation of translational initiation
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- eukaryotic translation initiation factor 3 complex, eIF3m
- eukaryotic 43S preinitiation complex
- membrane
- cytosol
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding
- metallopeptidase activity