Trappc2 Gene Summary [Rat]
Predicted to enable transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of gene expression; and skeletal system development. Predicted to be located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trappc2 |
| Official Name | trafficking protein particle complex 2 [Source:RGD Symbol;Acc:1306925] |
| Ensembl ID | ENSRNOG00000042276 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 2 |
| Synonyms | 1110066L09Rik, 1810064C02Rik, hYP38334, MIP-2A, RGD1306925, SEDL, SEDT, trafficking protein particle complex 2, trafficking protein particle complex subunit 2, TRAPPC2P1, TRS20, ZNF547L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trappc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel binding
- transcription factor binding
- Sedlin, N-terminal conserved region
- protein binding
- Longin-like domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- granules
- cytosol
- nucleoplasm
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trappc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- skeletal system development
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding